Electric Literature of 7752-72-9 ,Some common heterocyclic compound, 7752-72-9, molecular formula is C5H5ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
50 ml of POCl3 was added dropwise to a solution of 14.5 g (0.1 mol) of 4-hydroxyl-5-chloro-6-methylpyrimidine in 50 mL of toluene, the mixture was refluxed for 5-7 h after addition. After the reaction was over by Thin-Layer Chromatography monitoring, the reaction mixture was concentrated under reduced pressure to remove toluene and extra POCl3, and then poured into ice water. The water phase was extracted with ethyl acetate (3*50 mL), the organic phases were merged, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was purified through silica column (ethyl acetate/petroleum ether=1:5, as an eluent) to give14.43 g as yellow liquid with yield of 88.5%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7752-72-9, its application will become more common.
Reference:
Patent; Shenyang Sinochem Agrochemicals R&D Co., Ltd.; Liu, Changling; Guan, Aiying; Wang, Junfeng; Sun, Xufeng; Li, Zhinian; Zhang, Jinbo; Ban, Lanfeng; Ma, Sen; Lan, Jie; Xia, Xiaoli; Yang, Jinlong; (65 pag.)US2018/141961; (2018); A1;,
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