Adding a certain compound to certain chemical reactions, such as: 1753-50-0, 2-Chloropyrimidine-5-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H2ClN3, blongs to pyrimidines compound. Formula: C5H2ClN3
Step 24A: 2-r(3R.5R)-3.5-dimethylpiperazin-l-yllpyrimidine-5-carbonitrile (0915) To a suspension of (2R,6R)-2,6-dimethylpiperazine dihydrochloride (0.250 g, 1.34 mmol, 1.0 eq) and 2-chloropyrimidine-5-carbonitrile (0.187 g, 1.34 mmol, 1.0 eq) in acetonitrile (5 mL) was added triethylamine (0.93 mL, 6.7 mmol, 5.0 eq) and reaction mixture stirred at room temperature overnight. The resulting suspension was filtered to remove triethylamine hydrochloride and concentrated to yield 2-[(3R,5R)-3,5-dimethylpiperazin-l-yl]pyrimidine-5-carbonitrile 24a as an orange solid. The crude material was carried to Example 26 without further purification.
The synthetic route of 1753-50-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NEUROCRINE BIOSCIENCES, INC.; HARRIOTT, Nicole; PAGANO, Nicholas; (135 pag.)WO2017/79641; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia