Synthetic Route of 10070-92-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10070-92-5, name is Pyrimidine-5-carbaldehyde. A new synthetic method of this compound is introduced below.
Example P-5 A: Preparation of 5-propionyl-pyrimidine; 5.6 g of pyrimidine-5-carboxaldehyde in 100 ml of ether are slowly added dropwise, at 0-5C, to 18 ml of 3M ethylmagnesium bromide solution in ether. The yellowish suspension is stirred for 1 hour at 5C and then 30 ml of saturated NH4CI are added, with cooling. The phases are separated and the reaction solution is extracted 3 times with diethyl ether. The combined organic phases are washed with brine, filtered and concentrated. 3.14 g of a yellow oil are obtained, which-as the crude product-is reacted further. The intermediate is dissolved in 100 ml of methylene chloride and, after adding 10.26 g (1.2 eq. ) of pyridinium dichromate, is stirred for 20 hours at room temperature. The reaction mixture is filtered over Hyflo. The organic phase is washed with H2O/brine, dried and concentrated. After chromatography of the crude product on silica gel using ethyl acetate/hexane (1: 2), 0.95 g of the title product is obtained in the form of a colourless oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,10070-92-5, Pyrimidine-5-carbaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2005/47281; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia