Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde. A new synthetic method of this compound is introduced below., Recommanded Product: 2-Aminopyrimidine-5-carbaldehyde
General procedure: To a solution of amine and TEA in the indicated solvent is added acyl chloride dropwise at room temperature. After stirring for 16 hours, the mixture is concentrated.Following Procedure A using isonicotinoyl chloride (2.76 g, 19.. 5 rnmoi). dioxane (20 mL), 10 (800 mg, 6.5 mmol). and TEA (5.42 ml, 39 mmoi), react at 100 C and then dilute the mixture with EA (20 rnL), wash with water (30 mL) and brine (50 mL), concentrate, and purify with silica gel column chromatography (MeOH:DCM == 1:50) to give 27 as a white solid (400 mg, 27% yield). (MS: [M+H] 229.1)
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Reference:
Patent; IMMUNE SENSOR, LLC; THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM; ZHONG, Boyu; SUN, Lijun; SHI, Heping; LI, Jing; CHEN, Chuo; CHEN, Zhijian; (270 pag.)WO2017/176812; (2017); A1;,
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