Application of 1193-24-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1193-24-4 as follows.
A mixture of DMF (64 mL) and POCl3 (200 mL) at 0 C. was stirred for 1 h, treated with 4,6-pyrimidinediol (50.0 g, 446 mmol), and stirred for 0.5 h at rt, and then refluxed for 3 h. The volatiles were removed under reduced pressure, and the residue was poured into ice water and extracted six times with Et2O. The organic phase was washed with satd. aq. NaHCO3 and water, dried over Na2SO4, concentrated, and crystallized (EtOAc-petroleum ether) to give 4,6-dichloro-5-pyrimidinecarbaldehyde; LC-MS (ESI) m/z 177 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1193-24-4, its application will become more common.
Reference:
Patent; AMGEN INC.; US2011/245257; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia