The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5751-20-2, name is 2-(Methylthio)pyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 5751-20-2
2-Methylsulfanyl- 1 H-pyrimidin-6-one (4.81 g, 33.8 mmol), tert-butyl 4- [[4- [(iS)1-aminoethyllphenyllmethyllpiperazine-1-carboxylate (9.00 g, 28.2 mmol), and DME (56 mL) are split equally into three microwave vessels that are sealed and heated to 120 °C for 4 days. The reaction mixtures are allowed to cool to room temperature, combined, concentrated, and resuspended in CH2C12. The solids are filtered away and the filtrate is adsorbed onto silica gel and chromatographed on silica gel eluting with a gradient of 1- 7percent MeOH/CH2C12 to give the title compound as an off-white solid (10.55 g, 22.45 mmol,88percent purity). ES/MS (mlz): 414 (M+H).
With the rapid development of chemical substances, we look forward to future research findings about 5751-20-2.
Reference:
Patent; ELI LILLY AND COMPANY; LUMERAS AMADOR, Wenceslao; BAUER, Renato A.; BOULET, Serge Louis; BURKHOLDER, Timothy Paul; GILMOUR, Raymond; HAHN, Patric James; CARBALLARES MARTIN, Santiago; RANKOVIC, Zoran; (80 pag.)WO2017/213910; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia