Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14080-23-0, name is 2-Cyanopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 14080-23-0
l-(pyrimidin-2-yl)ethenone may be prepared as follows:A solution of pyrimidine-2-carbonitrile (75 g, 713.62 mmol) in THF (750 ml, 10 vol) was added dropwise to a solution of Methylmagnesium bromide (3.0M in diethylether) (357 ml, 1070.44 mmol) in THF (750 ml) at -5C. The resulting yellow suspension/solution was stirred at O0C overnight, and added to a rapidly stirred mixture of saturated ammonium chloride solution (750 ml) and 4M HCl (450 ml) at 5C, then pH adjusted to 1 with additional 2M HCl (5mL). The solution was warmed to 2O0C, stirred for 40 minutes, cooled to 00C then pH adjusted to 6.5-7 by addition of saturated K2CO3 solution (37.5 ml), warmed to 1O0C and separated. The aqueous phase was further extracted into ethyl acetate (5 x 750 ml). Sodium chloride was added to saturate the aqueous phase, which was extracted further into ethyl acetate (750 ml). The pH of the aqueous phase was adjusted to 7-8 by addition of saturated K2CO3 solution, and extracted further with ethyl acetate (3 x 750 ml). The combined organics were washed with saturated brine (750 ml), dried over MgSO4, filtered and concentrated in vacuo to give 78.9g of a brown solid. The crude product was purified by flash silica chromatography, elution in EtOAc. Pure fractions were evaporated to dryness to afford 1- (pyrimidin-2-yl)ethanone (65.Og, 74.6 %) as a yellow crystalline solid. 1H NMR (400.132 MHz, DMSO) delta 2.67 (3H, s), 7.72 (IH, t), 9.02 (2H, d); m/z (M+H)+, 123.
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Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/117051; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia