Synthetic Route of 25940-35-6 , The common heterocyclic compound, 25940-35-6, name is Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, molecular formula is C7H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Thionyl chloride (8.92 mL, 123 mmol) was added to pyrazolo[l,5-a]pyrimidine- 3-carboxylic acid (0.2 g, 1.2 mmol) and the mixture was stirred for 2 h at 80 C. The solvent was then removed under reduced pressure and the material was left on the high-vacuum for 3 h. The material was used without further purification.
The synthetic route of 25940-35-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIM, Jongwon; ALTMAN, Michael, D.; CHILDERS, Matthew, L.; GIBEAU, Craig, R.; HO, Ginny Dai; TSUI, Honchung; (80 pag.)WO2016/144844; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia