Adding a certain compound to certain chemical reactions, such as: 90213-67-5, 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, blongs to pyrimidines compound. Quality Control of 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine
A suspension of 2, 4-dichloro-7-methyl-7H-pyrrolo [2, 3-d] pyrimidine (200 mg, 0.99 mmol) , (+/-) -trans-methyl 3-aminobicyclo [2.2.2] octane-2-carboxylate (200 mg, 1.09 mmol) and K2CO3(273 mg, 1.98 mmol) in DMF (10 mL) was stirred at rt overnight. The reaction was quenched with H2O (100 mL) , and the resulting mixture was extracted with ethyl acetate (50 mL × 3) . The combined organic layers were washed with saturated brine (100 mL) , dried over anydrous Na2SO4,filtered, and the filtrate was concentrated in vacuo. The residue was purified by silica gel chromatograph (PE/EtOAc (v/v) = 3/1) to give the tilte compound as a white solid (144 mg, 42 %) .MS (ESI, pos. ion) m/z: 349.1 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,90213-67-5, 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (0 pag.)WO2018/157830; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia