Adding a certain compound to certain chemical reactions, such as: 1780-33-2, 4,6-Dichloro-2,5-dimethylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4,6-Dichloro-2,5-dimethylpyrimidine, blongs to pyrimidines compound. Recommanded Product: 4,6-Dichloro-2,5-dimethylpyrimidine
General procedure: Two solutions, one with the aryl halide (0.56 mmol, 1.0equivalent) in THF?H2O (2.5 mL, 3:2 v/v) and one with phenol (0.84mmol, 1.5 equivalent) and NaOH (0.84 mmol, 1.5 equivalent) in THF?H2O(2.5 mL, 3:2 v/v) were prepared and then introduced into Asia microfluidicreactor by Pump A & B.. The mixture was pumped through a preheated 1 mL glassmicrofluidic reactor at a predetermined flow rate to achieve the desiredresidence time. The crude product was collected in a flask and extracted withethyl acetate. The organic phase was combined, dried MgSO4 andconcentrated under reduced pressure. The isolated crude product was purifiedusing a prepacked silica cartridge on a Teledyne CombiFlash Rf 200instrument. Fractions corresponding to the product peak were combined andconcentrated using rotavap. For the synthesis of compound 3e and 3f correspondingsodium alkoxides were used as input for the second pump. 4-Chloro-6-(4-methoxy-2-methylphenoxy)-2,5-dimethylpyrimidine(3a). White solid (135 mg, 87percent). 1H NMR (CDCl3) d 2.08(s, 3H), 2.36 (s, 3H), 2.41 (s, 3H), 3.79 (s, 3H), 6.72?6.79 (m, 2H) and 6.94(d, J = 8.4 Hz, 1H); 13CNMR (CDCl3) d 11.6, 16.7, 25.5, 55.6, 111.9, 113.0, 116.2,122.6, 131.3, 144.9, 157.1, 160.1, 165.2 and 168.1; mass spectrum (APCI), m/zcalcd for C14H16ClN2O2 (M+H)+279.0895, found 279.0888.
The synthetic route of 1780-33-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Alam, Mohammad Parvez; Jagodzinska, Barbara; Campagna, Jesus; Spilman, Patricia; John, Varghese; Tetrahedron Letters; vol. 57; 19; (2016); p. 2059 – 2062;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia