Reference of 271-70-5, Adding some certain compound to certain chemical reactions, such as: 271-70-5, name is 7H-Pyrrolo[2,3-d]pyrimidine,molecular formula is C6H5N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 271-70-5.
To 7H-pyrrolo[2,3-]pyrimidine (6, 1.00 g, 8.39 mmol), (2,4-difluoro-3-formyl-phenyl)-carbamic acid benzyl ester (22, 2.93 g, 10.1 mmol), and potassium hydroxide (1.53 g, 27.3 mmol), 10.0 mL of methanol was added. The solution was allowed to stir at room temperature for 32 hours, then poured into 25 mL of water and 25 mL of saturated ammonium chloride and extracted 2×50 mL with ethyl acetate. The combined organic layer was concentrated under vacuum. The crude material was purified by silica gel column chromatography eluting with a gradient of 0-80% ethyl acetate in hexane (with 4% acetic acid) over 15 minutes. Appropriate fractions were combined and concentrated under vacuum to provide 1.066 g of a mixture of compounds 23 and 24, which was used in the next step without further purification. MS(ESI) [M+H+]+=335.4.
According to the analysis of related databases, 271-70-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Plexxikon, Inc.; US2009/286783; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia