In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14048-15-8, name is 2,4-Dimethoxypyrimidin-5-amine, the common compound, a new synthetic route is introduced below. name: 2,4-Dimethoxypyrimidin-5-amine
2,4-Dimethoxypyrimidin-5-amine (0.1 g) was dissolved in dry dichloromethane (5 mL)and pyridine (1 mL) and to this was added /’so-butylchloroformate (0.11 mL). Theresulting mixture was stirred at room temperature for 1 hour and was then poured into INhydrochloric acid and extracted into dichloromethane (2 x lOmL), dried (MgSO4), filteredand concentrated. The residue was dissolved in dry 1,2-dimethoxyethane (5 mL) andsodium hydride (60%, 0.032g) was added, followed by 2,3-dichlorobenzenesulphonylchloride (0.196 g). The reaction was stirred for 1 hour, poured into water and extractedinto ethyl acetate (2 x lOmL) and concentrated. The residue was dissolved in methanol (5mL) and IN sodium hydroxide (5 mL) added. The mixture was heated to reflux for 1hour, cooled and concentrated to 5 mL, acidified by the addition of 2N hydrochloric acidand extracted into ethyl acetate, dried (MgSO4), filtered and concentrated. The residue waspurified by chromatography on silica gel eluting with ethyl acetate /wo-hexanes (1/2) toafford the titled compound as a solid
The synthetic route of 14048-15-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2004/108690; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia