Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines
Following the preparation protocol of Section 5.1.2.1, the reaction mixtureof 2,4-dichloro-5-nitropyrimidine (1a) (250 mg, 1.29 mmol),DIEA (0.22 mL, 1.29 mmol) and aniline (120 mg, 1.29 mmol) inDCM (1 mL) was stirred at 0 C for 5 min to give the title compound2q as a yellow solid (277 mg, 85.8percent); mp 171?173 C; 1H NMR(400 MHz, DMSO d6) d (ppm) 10.45 (s, 1H), 9.16 (s, 1H), 7.54 (d,J = 8.0 Hz, 2H), 7.45 (t, J = 7.6 Hz, 2H), 7.29 (t, J = 7.2 Hz, 1H); 13CNMR (100 MHz, CDCl3) d (ppm) 164.26, 157.60, 153.44, 135.45,129.30, 126.65, 122.85; HRMS (ESI): m/z, Calcd. for C10H8O2N4Cl[M+H]+: 251.0330, Found 251.0329.
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Reference:
Article; Cui, Guonan; Jin, Jing; Chen, Hualong; Cao, Ran; Chen, Xiaoguang; Xu, Bailing; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 2186 – 2197;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia