Application of 131860-97-4, Adding some certain compound to certain chemical reactions, such as: 131860-97-4, name is (E)-Methyl 2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate,molecular formula is C15H13ClN2O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 131860-97-4.
A mixture of compound 6 (2.00 g, 6.24 mmol), Cs2CO3 (4.07 g, 12.48 mmol) and 2-cyanophenol (1.49 g, 12.48 mmol)in dry DMF (43 mL) was stirred at 85 C under nitrogen for 7 h. The resulting orange suspension was cooled to room temperature, poured into water and extracted with EtOAc. After evaporation of the solvent, the residue was purified by flash chromatography on silica gel using (hexane/EtOAc=4:1v/v) as eluent, to afford 7 (2.45 g, 97.5%); m.p. 115-116 C (lit.17 117-118 C); IR (KBr, numax/cm-1): 2230, 1707; 1H NMR: delta 8.43 (s, 1H), 7.75-7.67 (m, 2H), 7.52 (s, 1H), 7.44-7.32 (m,5H), 7.25 (d, 1H, J = 7.87 Hz), 6.44 (s, 1H), 3.78 (s, 3H), 3.66 (s, 3H); LC-MS (ESI): calcd for C22H18O5N3 ([M+H]+): 404.4; found: 404.1.
According to the analysis of related databases, 131860-97-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Liu, Yong-Gan; Luo, Yan; Lu, Yao; Journal of Chemical Research; vol. 39; 10; (2015); p. 586 – 589;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia