Adding a certain compound to certain chemical reactions, such as: 56621-90-0, 5-Amino-2-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 56621-90-0, blongs to pyrimidines compound. SDS of cas: 56621-90-0
A mixture of the pyrimidine from step 4 (100 mg, 0.77 mmol), indole boronic acid from step 3 (290 mg, 0.77 mmol), Pd(dppf)Cl2 (56 mg, 0.077 mmol), Na2CO3 (244 mg, 2.3 mmol), THF (20 mL) and H2O (2 mL) was refluxed under N2 overnight. The mixture was poured into water and extracted with CH2Cl2. The organic phase was combined, dried over Na2SO4 and filtered. The filtrate was purified by prep TLC (CH2Cl2/MeOH=20/1) to afford the product. MS (ESI) m/e (M+H+): 426.
The synthetic route of 56621-90-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck Sharp & Dohme Corp.; Coburn, Craig A.; Ludmerer, Steven W.; Liu, Kun; Wu, Hao; Soll, Richard; Zhong, Bin; Zhu, Jian; (155 pag.)US2019/127365; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
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