Reference of 1445-39-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1445-39-2, name is 2-Amino-5-iodopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 2-amino-5-iodopyrimidine (0.50 g, 2.26 mmol)in anh. DMF (100 mL) under direct nitrogen bubbling was added bis(tributyltin) (1.37 mL, 2.71 mmol)and Pd2dba3*CHCl3 (0.23 g, 0.23 mmol). Then, the reaction was heated to 65 C with stirring for3 h under direct nitrogen bubbling. After completion, the solvent was removed in vacuo to give ablack thick oil. The crude mixture was resuspended in EtOAc and filtered over a celite pad; then,the filtrate was concentrated in vacuo to give a dark liquid. Purification was performed using flashcolumn chromatography on silica (0-100% EtOAc in hexanes) to give the pure product as a yellowoil (0.75 g, 86%); Rf = 0.76 (1:1 EtOAc: Hex); 1H NMR (500 MHz, CDCl3)delta 8.17 (s, 2H), 6.08 (br, 2H),1.45-1.51 (m, 6H), 1.39-1.44 (m, 6H), 1.21-1.29 (m, 6H), 0.83-1.06 (m, 9H); 13C NMR (126 MHz, CDCl3) delta164.32, 163.16, 119.22, 28.84, 27.44, 13.57, 8.09; MS (ESI+) m/z calcd for C16H31N3Sn [M + H]+ 386.15,found: 386.19.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1445-39-2, 2-Amino-5-iodopyrimidine.
Reference:
Article; Yates, Mary K.; Chatterjee, Payel; Flint, Mike; Arefeayne, Yafet; Makuc, Damjan; Plavec, Janez; Spiropoulou, Christina F.; Seley-Radtke, Katherine L.; Molecules; vol. 24; 17; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia