Electric Literature of 1189169-37-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1189169-37-6, name is 1-(5-Bromopyrimidin-2-yl)ethanone, molecular formula is C6H5BrN2O, molecular weight is 201.02, as common compound, the synthetic route is as follows.
At -78 C, n-butyllithium (2.5 M, 4.38 mL, 10.94 mmol) was added to a THF (99 mL) solution containing N,N-bis(2,4- dimethoxybenzyl)ethanesulfonamide (4.07 g, 9.95 mmol, prepared following the procedure described in Example 467.0 employing2,4-methoxybenzylamine and 2,4- methoxybenzaldehyde). The resulting mixture was stirred for 30 min at -78 C. Next, a THF solution of 1-(5-bromopyrimidin-2-yl)ethanone (2.0 g, 9.95 mmol) was added at -78 C. Stirring was continued at -78 , and then the reaction was allowed to slowly warm to RT and stirred overnight. The reaction was then quenched with a saturated aqueous ammonium chloride solution and extracted with EtOAc (3 x 100 mL). After concentration, the product thus obtained was purified on silica eluting with a hexanes/EtOAc gradient (0-100%). Desired fractions were then pooled and concentrated in vacuo to give the title compound. LCMS-ESI (pos.) m/z: 629.9 (M+H2O).
Statistics shows that 1189169-37-6 is playing an increasingly important role. we look forward to future research findings about 1-(5-Bromopyrimidin-2-yl)ethanone.
Reference:
Patent; AMGEN INC.; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HORNE, Daniel B.; HOUZE, Jonathan; KALLER, Matthew R.; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; NISHIMURA, Nobuko; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YANG, Kevin; YEH, Wen-Chen; (700 pag.)WO2018/97945; (2018); A1;,
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