Related Products of 1119280-68-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1119280-68-0, name is 2-Chlorothieno[3,2-d]pyrimidine, molecular formula is C6H3ClN2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The intermediate 8 (1 equiv) and N-iodosuccinimide (3 equiv)were mixed in acetic acid and heated at 80 C for 24 h. The reactionwas then partitioned between water and EtOAc, and the aqueouslayer was extracted twice with EtOAc. The combined organic fractionswere washed with saline, dried over anhydrous Na2SO4, andfiltered. The filtrate was concentrated and purified using chromatographyto yield the intermediate 9.1H NMR (600 MHz, DMSO-d6)d 9.49 (s, 1H), 8.85 (s, 1H). MS (ESI) m/z(%): 296.5 [MH].
According to the analysis of related databases, 1119280-68-0, the application of this compound in the production field has become more and more popular.
Reference:
Article; Chen, Yixuan; Cheng, Maosheng; Hao, Chenzhou; Wang, Ruifeng; Wu, Tianxiao; Yang, Bowen; Yu, Sijia; Zhao, Dongmei; Zhao, Xiangxin; European Journal of Medicinal Chemistry; vol. 188; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia