Synthetic Route of 51-20-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 51-20-7, name is 5-Bromouracil. A new synthetic method of this compound is introduced below.
General procedure: Nitrogenous compounds (1eq. each) viz. thymine (for 2), 5-bromouracil (for 3), adenine (for 4), were first dissolved in warm DMSO. To this solution TEA and a solution of [6]-shogaol (1eq.) in DMSO was added. Reaction mixture was stirred at room temperature for 24h. The crude product was extracted using ethyl acetate (3×50mL). The combined organic layers were dried over Na2SO4, filtered, and concentrated under reduced pressure to get crude product as a syrupy residue which was further purified by flash chromatography to afford the corresponding pure product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,51-20-7, 5-Bromouracil, and friends who are interested can also refer to it.
Reference:
Article; Singh, Vinay Kr; Doharey, Pawan K.; Kumar, Vikash; Saxena; Siddiqi; Rathaur, Sushma; Narender, Tadigoppula; European Journal of Medicinal Chemistry; vol. 93; (2015); p. 74 – 82;,
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