Electric Literature of 153435-63-3, Adding some certain compound to certain chemical reactions, such as: 153435-63-3, name is 2-(Tributylstannyl)pyrimidine,molecular formula is C16H30N2Sn, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 153435-63-3.
Example 31 Cpy rimidin-2-y 1 { 1 -[4-(trifluoromethoxy )phenyl] cy cl obutyl} methanol To a solution of n-butyllithium (0.48 mL, 1.2 mmol, 2.5 M in hexanes) was added 2-(tributylstannyl)pyrimidine (369 mg, 1.0 mmol) in THF (6.0 mL) under nitrogen atmosphere at -95 C ~ -100 C. After 45 minutes, Example 3 IB (244 mg, 1.0 mmol) was added at -95 C, and the resulting mixture was stirred for an additional 30 min and then warmed to room temperature for 10 min. Saturated aq. NH4C1 was added and the mixture was extracted with dichloromethane (30 mL), concentrated and purified by Prep-TLC (petroleum ether : ethyl acetate =15:1 to 10:1) to give the title compound (30 mg, yield 9.26%). H NMR (400 MHz, CDCI3): 8.58 (d, J=8Hz, 2H), 7.17 (t, J=4Hz, IH), 6.95 (d, J=8Hz, 2H), 6.81 (d, J=8Hz, 2H), 5.24 (s, IH), 3.53 (br, IH), 3.05-2.97 (m, IH), 2.86-2.79 (m, IH), 2.46-2.35 (m,2H), 2.23- 2.1 1 (m, IH), 1.96-1.86 (m,lH). LC-MS: m/z (M+H)+ 325.1.
According to the analysis of related databases, 153435-63-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD; BAYBURT, Erol, K.; CLAPHAM, Bruce; COX, Phil, B.; DAANEN, Jerome, F.; GOMTSYAN, Arthur; KORT, Michael, E.; KYM, Philip, R.; VOIGHT, Eric, A.; WO2012/19315; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
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