Application of 39876-88-5, Adding some certain compound to certain chemical reactions, such as: 39876-88-5, name is 4-Chlorobenzofuro[3,2-d]pyrimidine,molecular formula is C10H5ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39876-88-5.
In a pressure vessel equipped with a magnetic stirring bar was added (4-bromo-2,6-difluorophenyl)methanamine.HC1 (1 g, 3.87 mmol), and 4-chlorobenzofuro[3,2-djpyrimidine (0.792 g, 3.87 mmol) in acetonitrile (20 mL). Hunig?s base (2.70 mL, 15.47 mmol) was added and the mixture was heated to 80 C in a preheated oil bath and allowed to stir for 48 hours overnight. Cool to RT and filter formed solids, wash with excess acetonitrile, filter and dry under vacuum to give 863 mg (5 7%) of N-(4-bromo-2,6-difluorobenzyl)benzofuro[3,2-djpyrimidin-4-amine as a fluffy white solid. LCMS (M+1) = 389.6 and 391.6.
According to the analysis of related databases, 39876-88-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
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