In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7627-39-6, name is 2,4-Dichloro-5-(ethoxymethyl)pyrimidine, the common compound, a new synthetic route is introduced below. Product Details of 7627-39-6
Sodium bicarbonate (700.67 mg, 8.34 mmol) was added to 4 mL of dry DMSO.2,4-dichloro-5 -(ethoxymethyl)pyrimidine (172.7 mg, 0.8300 mmol) was added followed by glutathione (256.32 mg, 0.83 00 mmol). The reaction was stirred at room temperature for 48 h. Once judged complete, the reaction was filtered and then diluted with 0.5 mL of water and purified directly by reverse phase prep-HPLC (10-95% MeCN/Water, 0.1% TFA) to give (2S)-2- amino-5 -oxo-5 – [[( 1R)-2-(carboxymethylamino)- 1 -[ [2-chloro-5 -(ethoxymethyl)pyrimidin-4- yl]sulfanylmethyl]-2-oxo-ethyl]amino]pentanoic acid (25 mg, 0.0523 mmol, 6.3 % yield) (VI-) MS m/z (M+H)= 478.14.
The synthetic route of 7627-39-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CELGENE CAR LLC; GUO, Jian; MALONA, John; RUCHELMAN, Alexander L.; SURAPANENI, Sekhar S.; (158 pag.)WO2018/170200; (2018); A1;,
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