Adding a certain compound to certain chemical reactions, such as: 5305-59-9, 6-Chloropyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5305-59-9, blongs to pyrimidines compound. category: pyrimidines
Add in the reaction flask4-amino-6-chloropyrimidine (6 g, 46.5 mmol),Tetrahydrofuran (75 mL) and pyridine (9.0 mL).Cyclopropylcarbonyl chloride (5.3 g, 50.7 mmol) was added dropwise at room temperature.10 minutes after the drop finished,The reaction solution was heated to 60 C,The reaction was incubated for 3 hours.After the reaction solution was cooled,Diluted with water (100 mL)Ethyl acetate was extracted twice,The organic phase was combined and used1N hydrochloric acid and saturated brine and dried.After concentration,Heated with n-hexane,To give N- (6-chloropyrimidin-4-yl)Cyclopropylcarboxamide(Pale yellow solid, 4.2 g, 45.8%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5305-59-9, its application will become more common.
Reference:
Patent; Zhang, Ruihao; (36 pag.)CN105949178; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia