Related Products of 6713-54-8 , The common heterocyclic compound, 6713-54-8, name is 2,4,6,8-Tetrahydroxypyrimido[5,4-d]pyrimidine, molecular formula is C6H4N4O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(f) Pyrimidine [5,4-d] pyrimidine-2,4,6,8-tetraol (10.9 g, 55.2 mmol) was added to a 500 three-necked flask,(8 · lml, 110 · Ommol, P = 1.638 g / ml), 200 ml of dioxane was reacted as a reaction solvent for 1 hour,After adding DMF (4.2 ml, 55.2 mmol) = 0.95 g / ml), the reaction was dark for 1.5 hours.After completion of the reaction, the solvent was removed under reduced pressure,The solid was extracted with hot toluene solution,The crude product was subjected to column chromatography using PE: DCM = 2: 1,To give a white solid 13. lg, yield 88.59%
The synthetic route of 6713-54-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Dalian Wanfu Pharmaceutical Co., Ltd.; Sun Qingfa; (9 pag.)CN106946887; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia