Adding a certain compound to certain chemical reactions, such as: 29274-24-6, 5-Chloropyrazolo[1,5-a]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 5-Chloropyrazolo[1,5-a]pyrimidine, blongs to pyrimidines compound. name: 5-Chloropyrazolo[1,5-a]pyrimidine
5-Chloropyrazolo[1,5-a]pyrimidine (1 g, 6.51 mmol) was dissolvedin anhydrous DMF (10 mL) and cooled to 5 C. Phosphorousoxychloride (1.82 mL, 19.5 mmol) was added and thereaction was allowed to warm slowly to RT and stirred for 16 h.The reaction was poured onto ice (200 g) and the pH wasadjusted to pH 10 with 1 M NaOH. The aqueous suspension wasextracted with CH2CL2 (100 mL) and the aqueous layer was washedwith CH2Cl2 (2 50 mL). The combined organic layers werewashed with water (2 70 mL), brine (50 mL), dried (WhatmanPS1 filter paper) and the solvent was removed in vacuo. The crudeproduct was adsorbed onto silica and purified by automated flashchromatography on silica gel (0-50% EtOAc-cyclohexane) to yieldthe title compound (8) (864 mg, 73%) as a colourless solid. 1H NMRdH (d6-DMSO, 300 MHz), 10.09 (s, 1H), 9.39 (d, J 7.2, 1H), 8.77 (s,1H), 7.49 (d, J 7.2, 1H); LC-MS tR 4.08 min; LC254 99.0%; m/z182.2/184.1 [M+H].
The synthetic route of 29274-24-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Phillipson, Louisa J.; Segal, David H.; Nero, Tracy L.; Parker, Michael W.; Wan, Soo San; De Silva, Melanie; Guthridge, Mark A.; Wei, Andrew H.; Burns, Christopher J.; Bioorganic and Medicinal Chemistry; vol. 23; 19; (2015); p. 6280 – 6296;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia