Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39551-54-7, name is 2,4-Dichloropyrido[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 39551-54-7
To a solution of 6h (200 mg, 0.30 mmol) and 2,4- dichloropyrido[3,2-cf|pyrimidine (59.6 mg, 0.30 mmol) in THF (3 mL) was added NN- diisopropylethylamine (0.21 mL, 1.19 mmol). After stirring at 75C for 18 h, the reaction was cooled to rt, diluted with EtOAc (10 mL), washed with water (10 mL) and brine (10 mL), dried over Na2SC>4, then filtered and concentrated in vacuo. The residue was subjected to silica gel chromatography eluting with hexanes-EtOAc to provide 6i. LC/MS (ESI) calculated for C15H20CIN5O: m/z 322.14, found 322.12 [M+H]+; tR = 0.98 min. on LC/MS Method A.
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Reference:
Patent; GILEAD SCIENCES, INC.; CHIN, Gregory; MACKMAN, Richard L.; MISH, Michael R.; ZABLOCKI, Jeff; (121 pag.)WO2018/45150; (2018); A1;,
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