Adding a certain compound to certain chemical reactions, such as: 74502-83-3, 2-(Chloromethyl)-4,6-dimethylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H9ClN2, blongs to pyrimidines compound. COA of Formula: C7H9ClN2
A room temperature solution of 6-( i-methyl-i H-pyrazol-4-yl)-4-(6-(piperazin- 1- yl)pyridin-3 -yl)pyrazolo[ 1,5 -a]pyridine-3 -carbonitrile dihydrochloride (Example 2; 0.018 g, 0.0394 mmol) in dry DMF (0.3 mL) and TEA (54.9 tL, 0.394 mmol) was treated with 2-(2- bromoethoxy)propane (0.0197 g, 0.118 mmol). The reaction mixture was stirred overnight at 75C, and then additional 2-(2-bromoethoxy)propane (1 eq) and TEA (1 eq) were added. The reaction mixture was allowed to stir 24 h at 75 C. After cooling to room temperature, the resulting reaction mixture was directly purified by C18 reverse phase chromatography (5-99 o ACNwater as the gradient eluent) to afford the title compound (7.4 mg, 41o yield). MS (apci) mz = 471.2 (M+H).used only 1.5 eq of the alkyl halide (2-(chloromethyl)-4,6-dimethylpyrimidine),10 eq of TEA, and was conducted at room temperature, but otherwise followed a similar procedure.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,74502-83-3, 2-(Chloromethyl)-4,6-dimethylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; ARRAY BIOPHARMA, INC.; ANDREWS, Steven W.; BLAKE, James F.; CHICARELLI, Mark J.; GOLOS, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; (594 pag.)WO2017/11776; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia