Adding a certain compound to certain chemical reactions, such as: 1193-21-1, 4,6-Dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1193-21-1, blongs to pyrimidines compound. Recommanded Product: 1193-21-1
298 mL of methanol is added to 387 mL (7.98 mol) of hydrazine monohydrate, and the mixture is cooled to 10C (internal temperature). To this mixed solution is gradually added 149 g (1.00 mol) of 4,6-dichloropyrimidine (at an internal temperature of 20C or lower), then the ice bath is removed to increase the temperature to room temperature, followed by stirring at the same temperature for 30 minutes. Thereafter, the mixture is further heated to an internal temperature of 60C, and is stirred at the same temperature for 5 hours. After completion of the reaction, 750 ml of water is added thereto, and then the mixture is cooled to an internal temperature of 8C with ice. Crystals precipitated are collected by filtration, spray-washed with water, then spray-washed with isopropanol. The crystals are dried at room temperature for 36 hours to obtain 119 g (white powder; yield: 84.5%) of the intermediate (28). Results of NMR measurement of the thus-obtained intermediate (28) are as follows. 1H-NMR (300 MHz, d-DMSO) 7.80 (s, 1H), 7.52 (s, 2H), 5.98 (s, 1H), 4.13 (s, 4H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1193-21-1, 4,6-Dichloropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; FUJIFILM Corporation; EP2253672; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia