Reference of 69034-12-4, Adding some certain compound to certain chemical reactions, such as: 69034-12-4, name is 2-Chloro-5-(trifluoromethyl)pyrimidine,molecular formula is C5H2ClF3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 69034-12-4.
Example 1.37: Preparation of 4-((lr,4r)-4-((l-(5-(Trifluoromethyl)pyrimidin-2-yl)piperidin- 4-yl)methoxy)cyclohexyl)nicotinonitrile (Compound 59).; A mixture of 4-((lr,4r)-4-(piperidin-4-ylmethoxy)cyclohexyl)nicotinonitriledihydrochloride (27 mg, 72.52 muetaiotaomicron), 2-chloro-5-(trifluoromethyl)pyrimidine (0.03 ml, 0.164 mmol), and potassium carbonate (50 mg, 0.362 mmol) in 1 ml iPrOH was heated under micorwave irradiation at 85C for 2 h. Mixture was purified by HPLC (CH3CN/H20 gradient + 0.1% TFA). Fractions containing desired product were partly concentrated and residue was extracted with 1 M NaOH and CH2C12. Organic phases were dried over MgS04, filtered, and concentrated to give 4-((lr,4r)-4-((l-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4- yl)methoxy)cyclohexyl)nicotinonitrile (14.6 mg, 32.77 muetaiotaomicron, 45.2 %) as a white solid. Exact mass calculated for C23H26F3N50: 445.21, found: LCMS m/z = 446.4 (M+H+); lU NMR (400 MHz, CDC13) delta ppm 1.17-1.28 (m, 2H), 1.41-1.62 (m, 4H), 1.85-2.04 (m, 5H), 2.18-2.24 (m, 2H), 2.90-2.99 (m, 3H), 3.26-3.33 (m, 1H), 3.38 (d, = 6.0 Hz, 2H), 4.84-4.90 (m, 2H), 7.28 (d, = 5.3 Hz, 1H), 8.47 (s, 2H), 8.80 (d, = 5.3 Hz, 1H), 8.81 (s, 1H).
According to the analysis of related databases, 69034-12-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; HAN, Sangdon; LEHMANN, Juerg; THORESEN, Lars; WO2012/135570; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia