Electric Literature of 3680-69-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (8 g, 52.3 mmol) in CH2Cl2 (200 ml) was added NIS (14 g, 62.5 ml). The mixture was stirred at rt for 5 h. LC- MS indicated complete reaction. The mixture was filtered and the filtered solid was washed with CH2Cl2 (50 ml), followed by hot water (500 ml). The solid was then dried in vacuum oven at 40 C for 2 days to give 4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, MM as a gray solid (13.6 g, 93%). 1H NMR (DMSO-d6) delta 12.97 (br s, 1H), 8.60 (s, 1H), 7.95 (s, 1H). LC/MS m/z 279.9 (M+H).
According to the analysis of related databases, 3680-69-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CHIMERIX, INC.; ALMOND, Merrick; LANIER, Ernest, Randall; MUSSO, David, Lee; WARE, Roy; WO2010/135520; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia