Related Products of 57489-77-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 57489-77-7, name is 5,7-Dichloropyrazolo[1,5-a]pyrimidine. A new synthetic method of this compound is introduced below.
To A solution of 5, 7-DICHLOROPYRAZOLO [1, 5-A] PYRIMIDINE (IV) (2 g) in 2-propanol (25 ml) containing N, N-DIISOPROPYLETHYLAMINE (2 equivalents) was added the amine RNHZ (1.2 equivalents). The reaction was heated overnight at 80 oC and the solvent removed in VACUO. The residue was partitioned between water and dichloromethane and the ORGANIC PHASE WAS WASHED WITH WATER, BRINE AND DRIED OVER MGS04. REMOVAL of the solvent in VACUA yielded the product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,57489-77-7, 5,7-Dichloropyrazolo[1,5-a]pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; TEIJIN PHARMA LIMITED; WO2004/81013; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia