Reference of 39876-88-5, Adding some certain compound to certain chemical reactions, such as: 39876-88-5, name is 4-Chlorobenzofuro[3,2-d]pyrimidine,molecular formula is C10H5ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39876-88-5.
4-Chlorobenzofuro[3,2-djpyrimidine (500 mg, 2.44 mmol), 6-methyl-2-vinyl-1,3 ,6,2-dioxazaborocane-4,8-dione (492 mg, 2.69 mmol), chloro(2-dicyclohexylphosphino-2?,6?-dimethoxy- 1,1 ?-biphenyl) [2-(2?-amino- 1,1?-biphenyl)jpalladium(II) (176 mg, 0.244 mmol), potassium phosphate tribasic (3.89 g, 18.3 mmol) were combined under N2 (g). 1,4-Dioxane (20 ml) and water (4.0 ml) was added under N2 (g). The reaction was stirred at 80 C for 1 hr. The reaction was concentrated, adsorbed onto celite and was purified on silica gel (Biotage,EtOAc/hexanes gradient, 0-100% over 10 CVs) to give the expected product 4- vinylbenzofuro[3,2-djpyrimidine (254 mg, 1.30 mmol, 53.0 % yield) LCMS (M+H) =196.80.
According to the analysis of related databases, 39876-88-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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