With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.21236-97-5, name is 6-Amino-3-methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H7N3O2, molecular weight is 141.128, as common compound, the synthetic route is as follows.SDS of cas: 21236-97-5
General procedure: Dinitrile 3a (1 mmol, 0.232 g), PhCHO (1 mmol, 0.106 g), and uracil 5a (1 mmol, 0.155 g) were added to a round-bottomed flask containing EtOH (5 mL). Et3N (0.05 mmol) was added, and the mixture was refluxed for 5 h. The product that formed was collected by filtration and recrystallized from EtOH as a white solid; yield: 0.380 g (80%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,21236-97-5, 6-Amino-3-methylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.
Reference:
Article; Naidu, P. Seetham; Kolita, Sinki; Majumder, Swarup; Bhuyan, Pulak J.; Synthesis; vol. 47; 5; (2015); p. 701 – 711;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia