Related Products of 302964-08-5 ,Some common heterocyclic compound, 302964-08-5, molecular formula is C16H13Cl2N5OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-oxa-6-azaspiro [3,3] heptane oxalate (128 mg, 0.4 mmol) was added to a solution of 2 – ((6-chloro-2-methylpyrimidin-4-yl) -N- (2-chloro-6-methylphenyl) thiazole-5-carboxamide (158 mg, 0.4 mmo 1) and N, N-diisopropylethylamine ( 56 mL, 1.6 mmo 1) , 4-dioxane (5 mL), heated to reflux, reacted overnight, TLC was monitoredMeasured raw material disappeared. The reaction was stopped at room temperature and the solvent was removed. The resulting solid was washed twice with methanol and diethyl ether and subjected to column chromatography to give a white solid (10 mg, 5% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,302964-08-5, its application will become more common.
Reference:
Patent; Fudan University; Dong, Xiaochun; Zhao, WeiLi; Zhao, Yichao; Lin, Zhaohu; Lu, Xiuhong; Wang, Wen; Dong, Qian; (12 pag.)CN104151321; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
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