Synthetic Route of 5750-76-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5750-76-5, name is 2,4,5-Trichloropyrimidine, molecular formula is C4HCl3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Id) 2-Amino-N-methyl-benzamide (1.5g, 10 mmol) and 2,4,5-Trichloro-pyrimidine (1.31 ew) were combined in DMF (30 mL). Potassium carbonate (1.3 eq) was added the mixture heated to 750C for 4.5 h and stirred at room temperature overnight. The mixture was poured into water and the white precipitate that ensued was filtered and dried to give 2- (2,5-dichloro-pyrimidin-4-ylamino)-N-methyl-benzamide (2.7 g, 92%): 1H NMR (400 MHz, DMSOd6) I’ 12.19 (s, IH), 8.86 (s, IH), 8.54 – 8.48 (m, 2H), 7.81 (d, J =7.9 Hz, IH), 7.61 (t, J = 8.7 Hz, I H), 7.23 (t, J = 8.9 Hz, IH), 2.50 (d, J = 1.5 Hz, 3H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5750-76-5, 2,4,5-Trichloropyrimidine.
Reference:
Patent; CEPHALON, INC.; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2008/51547; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia