Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16097-63-5, name is 4-Chloro-2-(methylsulfanyl)-6-(trifluoromethyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H4ClF3N2S
Step 3: 274-02 (38 mg, 0.16 mmol) , 49-01 (30 mg, 0.13 mmol) and K2CO3 (28 mg, 0.2 mmol) was mixed together in dry DMF (2 mL) in a microwave tube, the reaction was microwaved at 90 for 2 hrs. cooled to r. t. water was added, and the organic layer was extracted with ethyl acetate for three times, the organic layer was combined, dried and further purified by flash column chromatography (EA/PE 1/8) to give 54 mg of 274-03 as a colorless oil, yield: 96. Mass (m/z) : 430.15, [M+H] +.
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Reference:
Patent; NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING; ZHANG, Zhiyuan; WANG, Xiaodong; HUANG, Shaoqiang; JIANG, Xian; LI, Li; ZHANG, Zhaolan; HAN, Jianguang; (189 pag.)WO2018/14802; (2018); A1;,
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