Electric Literature of 1211443-61-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1211443-61-6, name is 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, molecular formula is C14H17ClN4O, molecular weight is 292.76, as common compound, the synthetic route is as follows.
Method-1 To the solution of tert-butyl 4-(6-aminopyridin-3 -yl) piperazine- 1 -carboxylate (100 g) and 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3 -d]pyrimidine-6- carboxamide (100 g) in acetonitrile (1000 ml) was added sodium hydride (34 g) and copper (I) iodide (3.25 g) at 20-30C. The reaction mixture was placed undernitrogen for 1 hr at 70-80C. After completion of the reaction, methanol (50 ml) was added followed by addition of distilled water. The reaction mass was slowly cooled to 20-30C and stirred for 2-3 hrs. The solid was collected by filtration to give off white to light grey solid (125 g).Yield: 65.0 %; HPLC Purity: 99.7%. 1H MR (400 MHz CDC13) delta ppm 8.70 (s, 1H), 8.38-8.36 (d, J=9.2, 1H), 8.02 (d, J=2.4, 2H), 7.35-7.32 (dd, J=3.2, J=9.2, 1H), 6.43(s, 1H), 4.81-4.74 (m, 1H), 3.61(t, 4H), 3.15 ( s, 6H), 3.09 ( t, 4 H), 2.62-2.53 (m, 2H), 2.08-2.0 (m, 4H), 1.75-1.64 (m, 2H), 1.49 (s, 9H).
The chemical industry reduces the impact on the environment during synthesis 1211443-61-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; FRESENIUS KABI ONCOLOGY LTD.; SOKHI, Sarbjot Singh; SINGH, Govind; LAHIRI, Saswata; PANDEY, Maneesh Kumar; TIWARI, Raj Narayan; SHUKLA, Sonu; MUSMADE, Sachin; DUA, Heena; CABRI, Walter; (70 pag.)WO2019/82143; (2019); A1;,
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