Electric Literature of 2244-11-3, Adding some certain compound to certain chemical reactions, such as: 2244-11-3, name is Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate,molecular formula is C4H4N2O5, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2244-11-3.
General procedure: 0.5 mmol of alloxan monohydrate (0.08 g) and suitable methyl ketone were suspended in 5 mL of glacial acetic acid and reacted in a Syncore apparatus set at the temperature of 115 C, shaking at 120 rpm and reaction time 3 h. All the targeted compounds precipitated after cooling and were recrystallized from ethanol. Compounds 19 and 20 were obtained as a mixture in a 36:64 ratio (total yield 75%); chromatographic purification of the crude (gradient eluent: methanol in dichloromethane 0-10%) afforded the pure final compounds 5.1.2.9 5-[2-(4′-Acetylbiphen-4-yl)-2-oxoethyl]-5-hydroxy-hexahydropyrimidine-2,4,6-trione (15) 55% Yield, mp > 250 C (decomp. 235 C). 1H NMR delta 11.45 (s, 2H, NH), 8.05-8.08 (m, 4H), 7.90-7.93 (m, 4H), 7.31 (s, 1H, OH), 3.94 (s, 2H), 2.61 (s, 3H). Anal. % (C20H16N2O6) calculated: C 63.16, H 4.24, N 7.37; found C 63.30, H 4.43, N 7.44.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2244-11-3, Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Nicolotti, Orazio; Catto, Marco; Giangreco, Ilenia; Barletta, Maria; Leonetti, Francesco; Stefanachi, Angela; Pisani, Leonardo; Cellamare, Saverio; Tortorella, Paolo; Loiodice, Fulvio; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 58; (2012); p. 368 – 376;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia