Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7752-82-1, name is 5-Bromopyrimidin-2-amine. A new synthetic method of this compound is introduced below., Product Details of 7752-82-1
The compound 5-bromopyrimidin-2-amine 89a (2.6 g, 15 mmol) was dissolved in anhydrous tetrahydrofuran (50 mL), and after cooling to 0 C, sodium hydride (purity 60%, 1.32 g, 33 mmol) was added.After stirring at this temperature for 30 minutes, p-methoxybenzyl chloride (5.17 g, 33 mmol) was added and gradually warmed to room temperature.After stirring for 15 hours,The reaction was quenched with water (2 mL), the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 50/1 to 2/1),The target product 5-bromo-N, N-bis (4-methoxybenzyl) pyrimidin-2-amine 89b (5.5 g, pale yellow solid) was obtained, yield: 89%.
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Reference:
Patent; Beijing Nuochengjianhua Pharmaceutical Technology Co., Ltd.; Chen Xiangyang; Pang Yucheng; (142 pag.)CN110818641; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia