Synthetic Route of 14080-59-2, Adding some certain compound to certain chemical reactions, such as: 14080-59-2, name is 4-Chlorothieno[2,3-d]pyrimidine,molecular formula is C6H3ClN2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14080-59-2.
4-Chlorothieno[2,3-d]pyrimidine (10) (5.80 g, 34.0 mmol) was dissolved in dry THF (300 mL) under nitrogen, cooled to -78 C, n-butyllithium (1.1 equiv, 23.4 ml, 1.6 M in hexane) was added and the mixture stirred at -78 C for 4 h. An excess of solid carbon dioxide was added and the mixture allowed to warm up to room temperature overnight. The solvents were removed under reduced pressure, and the remaining solid was suspended in water (300 mL). The suspension was filtered over a pad of celite and the clear solution was acidified with conc. HCl under stirring. The precipitating colourless crystals were collected by filtration and dried. 65% yield; colourless crystals; mp 195 C (decomp.); 1H NMR (300 MHz, DMSO-d6): delta 9.01 (s, 1H), 8.07 (s, 1H) ppm. MS (ESI+): 256 ([MH++CH3CN]+, 100; 35Cl), 215 ([M+H]+, 12; 35Cl). IR (KBr): nu 3442, 3091, 1724 cm-1. Anal. (C7H3ClN2O2S; 214.63): C, H, N.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 14080-59-2, 4-Chlorothieno[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Beckers, Thomas; Sellmer, Andreas; Eichhorn, Emerich; Pongratz, Herwig; Schaechtele, Christoph; Totzke, Frank; Kelter, Gerhard; Krumbach, Rebekka; Fiebig, Heinz-Herbert; Boehmer, Frank-D.; Mahboobi, Siavosh; Bioorganic and Medicinal Chemistry; vol. 20; 1; (2012); p. 125 – 136;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia