Reference of 36082-50-5 ,Some common heterocyclic compound, 36082-50-5, molecular formula is C4HBrCl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
5-Bromo-2,4-dichloropyrimidine B1-a (2.28 g, 10 mmol) and 30 mL of tetrahydrofuran were sequentially added to a dry 100 mL one-necked flask, and a 2N aqueous sodium hydroxide solution (10 mL, 20 mmol) was stirred under ice-cooling. The reaction temperature was raised to room temperature and the reaction was stirred at room temperature for 6 hours. After completion of the reaction, the reaction solution was cooled to 0 C and the pH of the reaction solution was adjusted to 3-4 using a 6N hydrochloric acid solution. The mixture was extracted with chloroform (50 mL×3) and EtOAc (1.8 g, 86% yield).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 36082-50-5, 5-Bromo-2,4-dichloropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanghai Qingyu Pharmaceutical Technology Co., Ltd.; Zou Bin; Ma Shichao; Fu Xianlei; Dong Hongping; (130 pag.)CN109942556; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia