Reference of 49844-90-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 49844-90-8, name is 4-Chloro-2-(methylthio)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 4-chloro-2-(methylthio)pyrimidine (0.55 g, 3.42 mmol) and methyl tetrahydro-2/-/- pyran-4-carboxylate (494 mg, 3.42 mmol) in THF (5 ml.) at 30 C was added LHMDS (1 M in THF) (4.11 ml_, 4.1 1 mmol) dropwise. The reaction mixture was stirred at 30 C for 5 min then was poured into water (100 ml.) and extracted with EtOAc (2 x 200 ml_). The organic extract was washed with brine (1 x 100 ml_), dried (MgS04), filtered and solvent removed in vacuo to afford methyl 4-(2-(methylthio)pyrimidin-4-yl)tetrahydro-2/-/-pyran-4-carboxylate (915 mg, 3.24 mmol, 95% yield) as a pale yellow oil. Rt 1.74 min (HPLC acidic); m/z 269 (M+H)+ (ES+); 1H NMR (500 MHz, DMSO-d6) d 8.62 (d, J = 5.3 Hz, 1 H), 7.27 (d, J = 5.3 Hz, 1 H), 3.76-3.70 (m, 2H), 3.67 (s, 3H), 3.54-3.46 (m, 2H), 2.49 (s, 3H), 2.27-2.20 (m, 2H), 2.14-2.04 (m, 2H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 49844-90-8, 4-Chloro-2-(methylthio)pyrimidine.
Reference:
Patent; STEP PHARMA S.A.S.; QUDDUS, Abdul; NOVAK, Andrew; COUSIN, David; BLACKHAM, Emma; JONES, Geraint; WRIGGLESWORTH, Joseph; DUFFY, Lorna; BIRCH, Louise; GEORGE, Pascal; AHMED, Saleh; (267 pag.)WO2019/180244; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia