Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13036-50-5, name is 2-Chloro-4-phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Chloro-4-phenylpyrimidine
A solution of 2-chloro-4-phenylpyrimidine (245 mg, 0.59 mmol), 2-amino-N,N-dimethylpropanamide hydrochloride (294 mg, 1.93 mmol) and DIPEA (0.673 mL, 3.86 mmol) in acetonitrile (2.0 mL) was heated to 100 C for 16 h. The reaction mixture was concentrated and dissolved in ethyl acetate (15 mL) and washed with water (3 x 10 mL). The aqueous layers were then combined and washed with ethyl acetate (2 x 15 mL). The organic layers were combined and concentrated in vacuo. The crude material was purified using silica chromatography with a gradient of 0-100 % (3:1 ethyl acetate:ethanol + 1 % triethylamine)/cyclohexane. The relevant fractions were combined and concentrated in vacuo to yieldN,N-dimethyl-2-((4-phenylpyrimidin-2-yl)amino)propanamide (238 mg, 0.880 mmol, 69% yield) as a white powder. LCMS (High pH, ES+ ): tR = 0.92 min, [M+H]+ 271.2. 1H NMR (400 MHz, CDCl3) delta 1.45 (d, J = 6.8 Hz, 3H), 3.01 (s, 3H), 3.17 (s, 3H), 5.15 (qd, J=6.8, 5.1 Hz, 1H), 6.05 (d, J=5.1 Hz, 1 H), 6.98 (d, J = 5.31 Hz, 1H), 7.43-7.49 (m, 3H), 7.96-8.03 (m, 2H), 8.33 (d, J = 5.3 Hz, 1H). 13C NMR (101 MHz, CDCl3) delta 18.4, 35.9, 37.1, 46.8, 106.9, 127.0, 128.7, 130.5, 137.5, 158.6, 161.6, 173.3. HRMS: (C15H18N4O) [M+H]+ requires 271.1553, found [M+H]+ 271.1553. numax (neat): 3257, 1654, 1563, 1530, 1412, 767, 695, 656, 628 cm-1.
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Reference:
Article; Law, Robert P.; Ukuser, Sabri; Tape, Daniel T.; Talbot, Eric P. A.; Synthesis; vol. 49; 16; (2017); p. 3775 – 3793;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia