Synthetic Route of 7752-72-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7752-72-9, name is 5-Chloro-6-methylpyrimidin-4(3H)-one, molecular formula is C5H5ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: POCl3 (100 mL) was added dropwise to a solution of M-2 (0.36 mol)in toluene (150 mL), the mixture was refluxed for 3-5 h. The reactionmixture was concentrated under reduced pressure to remove tolueneand extra POCl3, and then poured into ice water. The water phase wasextracted with ethyl acetate (3 × 50 mL), the emerged organic phasewas successively washed with saturated sodium bicarbonate, dried overanhydrous magnesium sulfate, filtered and then concentrated underreduced pressure. The residue was purified through silica column togive M-3 as yellow liquid.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7752-72-9, 5-Chloro-6-methylpyrimidin-4(3H)-one.
Reference:
Article; Guan, Aiying; Wang, Mingan; Chen, Wei; Yang, Fan; Yang, Jinlong; Zhao, Yu; Li, Zhinian; Liu, Changling; Journal of Fluorine Chemistry; vol. 201; (2017); p. 49 – 54;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia