Reference of 1753-50-0 ,Some common heterocyclic compound, 1753-50-0, molecular formula is C5H2ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The crude compound 4 (383 mg, 1 mmol) was dissolved in 10 mL of N,N-dimethylformamide, followed by 2-chloro-5-cyanopyranidine 4f (139 mg, 1 mmol).Purchased in Haoyuan Chemical Technology Co., Ltd.),Barium carbonate (977mg, 3mmol),The mixture was heated to 80 C for 2 hours.The reaction solution was concentrated under reduced pressure.The resulting residue was beaten with 3 mL of methanol.filter,The title compound 4 (60 mg, yield: 12%) was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1753-50-0, its application will become more common.
Reference:
Patent; Jiangsu Hengrui Pharmaceutical Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.; Yang Fanglong; Fan Xing; Wang Yang; Qu Jian; Zhang Mingquan; He Feng; Tao Weikang; (93 pag.)CN110218218; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
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