Adding a certain compound to certain chemical reactions, such as: 7461-50-9, 2-Chloropyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H4ClN3, blongs to pyrimidines compound. Formula: C4H4ClN3
To a glass vial was added (4-methoxyphenyl)boronic acid (0.15 g, 1.0 mmol), 2-chloropyrimidin- 4-amine (0.13 mg, 1.0 mmol), Pd(Amphos)2Cl2 (35 mg, 0.050 mmol), a 2M solution of Na2C03 (0.75 mL, 1.5 mmol) and acetonitrile (2.5 mL). The mixture was degassed by nitrogen bubbling for 20 min. The reaction vial was sealed and stirred at 110 C in an oil bath for 2 h. The reaction mixture was cooled to room temperature, filtered and concentrated. The crude product was purified by flash chromatography on silica to give the title compound (141 mg, 70%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,7461-50-9, 2-Chloropyrimidin-4-amine, and friends who are interested can also refer to it.
Reference:
Patent; GENENTECH, INC.; BRYAN, Marian C.; CHAN, Bryan; HANAN, Emily; HEFFRON, Timothy; PURKEY, Hans; ELLIOTT, Richard Leonard; HEALD, Robert; KNIGHT, Jamie; LAINCHBURY, Michael; SEWARD, Eileen M.; WO2014/81718; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia