Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 37972-24-0, name is 2-Ethynylpyrimidine. A new synthetic method of this compound is introduced below., Computed Properties of C6H4N2
To a solution of 23lOOmg, 0.282mmo1) and 4(58.8mg, 0S65mmol) in 2OmL of Et3N was added Pd(PPh3)2Cl2 (991mg, 0Oi4minol) and Cul (538mg, 0O28minol). The mixture was protected with N2 atmosphere, then was heated at 70°C for 4 hours. TLC analysis showedcomplete conversion of starting material to a major product. The reaction mixture was then concentrated in vacua The crude product was purified by Prep-HPLC to give the target product Compound 123(22mg, yield: 23.59percent).LCMS: in/z 331 (M+H)?H NMR (400 MHz, CDCI3): 3 8.77 (d, 4.8 Hz, 2H), 7.92 (d, .J 2,4 Hz, 1H), 7.78-7.76 (m,2H), 7.34-7.32 (m, 2H), 729-726 (m, IH), 6.80 (d, J= 2.8 Hz, 111).
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Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia