Electric Literature of 5305-59-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5305-59-9, name is 6-Chloropyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: Step 1: Take a dry three-mouth reaction bottle and place the magnet.Add 4-amino-6-chloropyrimidine (1 eq), KI (0.5 eq),It was dissolved in absolute ethanol (35 mL).After stirring for 10 min on a magnetic stirrer, trifluoroacetic acid (200 mL) was added.activation. After about 1 h, add absolute ethanol (15 mL)The dissolved substituted aniline (0.8 eq) was reacted. Note that it should be added in the form of dropping to achieve the effect of long-term excessive reaction, and the dropping time is controlled at about 1 h. Step 2: The progress of the reaction and the reaction effect were examined by the TLC method. Generally, after 36 hours of reaction, the reaction is almost complete. After the reaction is completed, the solvent is dried in absolute ethanol, and then a certain amount of ethyl acetate is added to dissolve. First remove the acid with an appropriate amount of 20% sodium bicarbonate solution, then add a certain amount of 50% sodium chloride solution to extract the layer, collect the organic layer and spin dry to a certain amount, add an appropriate amount of anhydrous sodium sulfate, Water overnight.Step 3: suction filtration, sand making, weigh 15 to 20 times of the total amount of raw materials, and collect the product points through the column. Generally use petroleum ether: ethyl acetate = 2:1 to pass the first point (aniline point), petroleum ether: ethyl acetate = 1:1 to pass the second point (pyrimidine point), ethyl acetate Or methanol rushed out of the product point. The spin-dried product points were collected, dried in an oven, mass spectrometrically and nuclear magnetically verified.
According to the analysis of related databases, 5305-59-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Wenzhou Medical University; Ye Faqing; Cheng Donghua; Han Chao; Pan Suwei; Pan Yaqian; Xie Zixin; (11 pag.)CN109053592; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia