Application of 582313-57-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 582313-57-3, name is 4-Chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H3ClFN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Vial A: Add to dry round bottom flask (purged by N2)(S,S)-DACH-naphthyltrozine ligand (1.13 g, 1.43 mmol) andPd2(dba)3.CHCl3 (493 mg, 0.48 mmol).The vial was purged four times with N2 and added DCE (50 mL,Sprayed by N2 for 30 minutes). The black solution was stirred for 30 minutes at 12°C,A red-brown solution was obtained at this time.Vial B: To dry round bottom flask(by N2 purification) BB-1 (7155 mg, 23.82 mmol) was added,4-chloro-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine (4.5 g, 26.23 mmol) andCs2 CO3 (8.54 g, 26.2 mmol). The vial was purged with N2 five times and DCE (50 mL) was added followed by addition of the contents of vial A via syringe.The reaction was stirred at 12 °C under N2 for 24 hours. The reaction mixture was filtered and concentrated to a brown gum. The crude residue was purified by flash biotage (120 g, tannin, EtOAc/petroleum ether = 15percent) to give NN-1 (6.4 g, 76percent) as an off-white solid.
According to the analysis of related databases, 582313-57-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER INC.; KUMPF, ROBERT ARNOLD; MCALPINE, INDRAWAN JAMES; MCTIGUE, MICHELE ANN; PATMAN, RYAN; RUI, EUGENE YUANJIN; TATLOCK, JOHN HOWARD; TRAN-DUBE, MICHELLE BICH; WYTHES, MARTIN JAMES; (445 pag.)TW2018/2074; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia