Synthetic Route of 1439-10-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1439-10-7, name is 4-Amino-5-bromopyrimidine, molecular formula is C4H4BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Steps 1-3 A mixture of N-Boc-6-bromoindoline (0.66 g, 2.2 mmol), bis(pinacolato)diboron (1.118 g, 4.4 mmol), KOAc (0.65 g, 6.6 mmol.), and PdCl2(dppf) (0.069 g, 0.08 mmol) in dioxane (8 mL) was heated at 100 C. for 1.5 h in a 15 mL sealed tube and then cooled to RT. The reaction was treated with 4-amino-5-bromopyrimidine (0.76 g, 4.4 mmol) and aqueous K2CO3 (4 mL, 1M) and heated at 100 C. overnight. The mixture was diluted with aqueous K2CO3 and extracted with DCM. The organic extracts were dried over MgSO4 and concentrated. Chromatography (0-10% of (9:1 MeOH/NH3) in CH2Cl2) afforded 3A (657 mg) as a brown oil.
According to the analysis of related databases, 1439-10-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SCHERING CORPORATION AND PHARMACOPEIA, LLC; PHARMACOPEIA, INC.; US2010/197562; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia